Potential therapeutic benefits of melatonin in the recovery of circadian rhythms have been demonstrated in a growing number of studies in ASD.
Potential therapeutic benefits of melatonin in the recovery of circadian rhythms have been demonstrated in a growing number of studies in ASD.Tags: Professor Ward Churchill Essay 911What Impact Did The 95 Theses Have On SocietyThesis Opportunities In EuropeArchitecture Thesis Report On Museum5 Paragraph Essay On World War OneFrom Great Paragraphs To Great Essays Second EditionEnglish Essay Comparing Two PoemsWhat Is An Introduction In An Essay
The last part of the book is dedicated to basic studies highlighting the importance of investigating mouse models to unravel the molecular mechanisms underlying ASD pathogenesis.
Two review articles, respectively by Cellot and Cherubini (13) and Giovedí and coworkers (14), address the role of GABAergic neurotransmission and synaptic vesicle proteins in the pathogenesis of ASD, strengthening the notion of ASD as a “synaptic neuropathology”.
ASD children treated with a ketogenic diet (KGD) showed decreased seizure frequencies and improved learning abilities and social skills, as proposed by Napoli and coworkers (5); however, replications of this investigation are urgently awaited to have of a clearer picture of KGD role in ASD.
Excitation and inhibition (E/I) imbalance in ASD has been demonstrated in preclinical models, and targeted treatments directed either to reduce excessive glutamatergic transmission or increase inhibition through stimulation of GABAergic signaling have been introduced with promising preliminary results.
New ASD treatments are emerging and deserve to be mentioned.
Retrolisthesis 2mm - Autism Treatment Research Paper
A number of novel medications have been used off-label in various studies, including drugs approved for Alzheimer’s disease, as reviewed by Rossignol and Frye (3).In the past 10 years, research on autism spectrum disorders (ASD) has made a considerable progress, leading to the identification of a number of genes and signaling pathways associated to ASD pathogenesis.Nevertheless, our understanding of the complexity of these disorders remains elusive, and effective treatments are still lacking (1).This new conceptualization paves the way to a modern treatment approach to this group of disorders once thought as hard wired and not amenable of changing, as discussed in the papers by Pini and colleagues (6) and Canitano (7).The role of melatonin in the establishment of circadian rhythms and the synchronization of peripheral oscillators is probably linked to the synchrony of motor, emotional, and social rhythms that are altered in ASD.In this e-book, we present 16 articles addressing several different aspects of both clinical and basic research on ASD.A particular emphasis is put on the efforts that are currently made to identify reliable diagnostic markers and novel therapeutic strategies, as well as on the progress of ongoing clinical trials.Drugs commonly used to treat mitochondrial diseases such as L-carnitine, complex B vitamins, antioxidants etc.have been found to improve ASD symptoms in some studies, but results are still conflicting and more research is needed.The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Pini G, Scusa MF, Benincasa A, Bottiglioni I, Congiu L, Vadhatpour C, et al.Repeated insulin-like growth factor 1 treatment in a patient with rett syndrome: a single case study. doi:10.3389/fped.2014.00052 Pubmed Abstract | Pubmed Full Text | Cross Ref Full Text | Google Scholar 7. New experimental treatments for core social domain in autism spectrum disorders. doi:10.3389/fped.2014.00061 Pubmed Abstract | Pubmed Full Text | Cross Ref Full Text | Google Scholar 8.