The salicylic acid and aspirin may cause irritation to your skin or eyes, but are basically not hazardous.An excess of these can be disposed of in the sink or, if packaged, in the trash.Make sure that the water bath is located directly under the hood at your lab bench. (NOTE: The hot water bath will be used again later in the procedure.) A.
Record your observations and conclusions on the Data Sheet. Measure the melting point range of your synthesized aspirin with the Meltemp Apparatus as demonstrated by your lab instructor and compare to the value for pure aspirin of 138-140 A.
Weigh the aspirin and calculate the theoretical (maximum) yield.
SAFETY CONSIDERATIONS Wear goggles throughout this experiment.
This experiment uses salicylic acid, acetic anhydride and phosphoric acid.
Apparently this comes from acetylation (A-), together with Spirin, part of the name for Meadow-sweet (Spiraea ulmaria), a plant rich in salicylates.
Friedrich Bayer, the employer of Hoffman, patented the name and began marketing the product in 1899. Bayer's company set up by himself, is generally reckoned to have been the first pharmaceutical company, and the production of aspirin is generally accepted to have laid the foundation of the modern pharmaceutical industry.
Use them only in the hood and be sure the hood fan is on! Excess chemicals must be disposed of in the plastic tub of water.
This will convert the acetic anhydride to vinegar and dilute the sulfuric acid.
If you spill a lot of either of these, notify your instructor.). Using the graduated cylinder located under the hood, measure out 7.00 m L of acetic anhydride and add this to the flask.
Transfer this to a 125 m L Erlenmeyer flask using a powder funnel. Be sure to do this in the hood and wearing your goggles.